Top purpura Articles in Dermatology

Deficiency of ADAMTS13 in thrombotic thrombocytopenic purpura
International Journal of Hematology, 10/12/2009

Tsai H–M – Mutations of the gene are detected in patients with the congenital form of thrombotic thrombocytopenic purpura. In the circulation, proteolysis of von Willebrand factor is critical in regulating vWF–platelet ... basis for a rational approach to improving the diagnosis and treatment of thrombotic thrombocytopenic purpura. [more...]

A purpuric rash
Australian Family Physician, 11/09/2009

aspect of both arms...‘Sports purpura’ are nonpalpable purpura that occur on exposed parts of the body, typically the arms, and result mainly from mechanical trauma. This case study illustrates that surfing is one of the many activities that may cause ‘sports purpura’. As sports people may not make ... the triggering activity, it is important to ask about participation in sports when a patient presents with purpuric rash. [more...]

Refractory chronic immune thrombocytopenic purpura in a child with acute lymphoblastic leukemia
International Journal of Hematology, 10/13/2009

Horino S et al. – Immune thrombocytopenic purpura (ITP) has been associated with several hematologic malignancies such as Hodgkin and non–Hodgkin lymphomas and chronic lymphocytic leukemia ... lymphoblastic leukemia (ALL). This is the first child case of chronic ITP during chemotherapy for ALL and splenectomy was effective in this patient. [more...]

Immune thrombocytopenia associated with Mycoplasma pneumoniae infection: a case report and review of literature
Blood Coagulation & Fibrinolysis, 10/07/2009

immune thrombocytopenic purpura during an acute mycoplasma infection. Immune thrombocytopenic purpura should be considered early in patients with thrombocytopenia and mycoplasma infections, with the institution of usual therapy for immune thrombocytopenic purpura. [more...]

Mutation of the H-bond acceptor S119 in the ADAMTS13 metalloprotease domain reduces secretion and substrate turnover in a patient with congenital thrombotic thrombocytopenic purpura
Blood, 10/02/2009

Feys HB et al. – Hereditary thrombotic thrombocytopenic purpura is caused by mutations in ADAMTS13 resulting in defective processing of von Willebrand factor (VWF) which causes ... the functional and structural role of a recently identified ADAMTS13 metalloprotease domain mutation S119F was investigated. The S119–W262 H–bond is crucial for maximal turnover. [more...]

Romiplostim in chronic immune thrombocytopenic purpura
Clinical Therapeutics, 10/23/2009

Cersosimo RJ – Based on the findings from this review, romiplostim administration has been associated with a durable platelet response in these patients with refractory chronic ITP. Romiplostim has been found to be generally well ... clinical pharmacology,coagulation/bleeding dz,pharmacology/therapy,other drugs [more...]

Celiac disease, Behçet, and idiopathic thrombocytopenic purpura in siblings of a patient with multiple sclerosis
Multiple Sclerosis, 10/26/2009

Yamout B et al. – Multiple sclerosis (MS) is a demyelinating disease of uncertain etiology. Many genetic and environmental risk factors have been associated with this disease ... D deficiency. The authors report a 30–year–old woman with MS, the product of consanguineous marriage, and three siblings with three different autoimmune diseases: idiopathic thrombocytopenic purpura, celiac disease, and Behçet’s disease. [more...]

Idiopathic thrombocytopenic purpura: Pathophysiology and management
International Journal of Hematology, 10/12/2009

Ahn YS et al. – The management of ITP should include the search for and elimination of underlying causes and careful evaluation of hemostasis. Therapy is divided into definitive vs symptomatic measures. The former including ... lasting remission after therapy was stopped, while the later including glucocorticoids, gammaglobuin, antiD antibodies and others increases platelet counts but seldom sustains remission upon withdrawal. [more...]

Priapism and Penile Gangrene Due to Thrombotic Thrombocytopenic Purpura
Urology, 11/09/2009

Kwok B et al. – A 51–year–old man presented with 4 days of idiopathic ischemic priapism. Partial detumescence was achieved with aspiration and injection with intracorporeal adrenaline. Gangrene of the penis ... thrombocytopenic purpura has not been reported previously in published data. [more...]

Medical treatments for idiopathic thrombocytopenic purpura during pregnancy
Cochrane Reviews, 10/27/2009

Marti–Carvajal AJ et al. – Current evidence from one randomised controlled trial indicates that betamethasone does not reduce the risk of neonatal thrombocytopenia and neonatal bleeding in ITP during pregnancy ... clinical and pregnancy outcomes reported. The researchers used no treatment in the control group, which may have increased the risk of performance bias in the trial. [more...]