Top melanoma Articles in Dermatology

Loss of SNF5 expression correlates with poor patient survival in melanoma
Clinical Cancer Research, 10/12/2009

Lin H et al. – Our data indicate that SNF5 may be an important marker for human melanoma progression and prognosis as well as a potential therapeutic target. Methods Using tissue microarry and ... melanomas, and 48 metastatic melanomas evaluated Studied chemosensitivity of melanoma cells with reduced SNF5 expression by siRNA using cell survival and apoptosis assays Results SNF5 expression reduced in metastatic melanoma compared with dysplastic nevi , in ... advanced primary melanoma (Clark's level V) compared with low risk Clark's level II melanoma , and in melanoma at sun-exposed sites compared with sun-protected sites Strong correlation between negative SNF5 expression and worse 5-year survival in melanoma patients Multivariate Cox ... analysis revealed negative SNF5 expression is independent prognostic factor to predict patient outcome in primary melanomas Knockdown of SNF5 in melanoma cell lines resulted in significant chemoresistance [more...]

Slow-growing melanoma: a dermoscopy follow-up study
British Journal of Dermatology, 10/05/2009

Argenziano G et al. – The study provides evidence for the existence of a subgroup of slow–growing melanomas, which may explain the increase in the incidence of thin melanoma, despite stable rates of thick melanoma and melanoma&ndash ... mortality. [more...]

ADAM10 Is Upregulated in Melanoma Metastasis Compared with Primary Melanoma
Journal of Investigative Dermatology, 11/03/2009

Gutwein P et al. – The authors data demonstrate that ADAM10 and L1–CAM have important roles during melanoma progression and both molecules represent attractive targets for therapeutical intervention of melanomas. [more...]

Dormancy of metastatic melanoma
Pigment Cell & Melanoma Research, 11/11/2009

Ossowski L et al. – Metastatic dormancy of melanoma has not received sufficient attention, most likely because once detectable, metastasis is almost invariably fatal and, understandably, the focus has been on finding ways to prolong life of patients with overt ... analysis of the published clinical and experimental data on melanoma indicates that some aspect of melanoma biology imitate traits recently associated with dormancy in other solid cancers. Among them the ability of some melanomas to disseminate early during primary tumor progression and once ... dermatologic oncology,dermatology [more...]

KIT as a Therapeutic Target in Melanoma
Journal of Investigative Dermatology, 10/23/2009

Bastian BC et al. – Emerging evidence suggests that melanomas with KIT activation may also respond to KIT inhibitors that are already in clinical use. If confirmed in ongoing clinical trials, this experience would underscore the importance of ... among melanomas, representing a first decisive step toward the individualized and mechanism–based treatment of melanoma. [more...]

Cytoskeleton alterations in melanoma: aberrant expression of cortactin, an actin-binding adapter protein, correlates with melanocytic tumor progression
Modern Pathology, 11/11/2009

Xu X–Z et al. – The data, in conjunction with outcome data on several other types of human cancers and experimental data from melanoma cell lines, supports a ... potential role of aberrant cortactin expression in melanoma tumor progression and a rational for targeting key elements of actin–signaling pathway for developmental therapeutics in melanomas. [more...]

Distinct MHC gene expression patterns during progression of melanoma
Genes, Chromosomes and Cancer, 11/02/2009

Degenhardt Y et al. – These results infer a dynamic role of MHC function in melanoma progression. The authors propose potential mechanisms for the overexpression of MHC molecules in earlier stages of melanoma as well as for its downregulation in metastatic melanomas. [more...]

Spitzoid melanoma
Clinics in Dermatology, 11/11/2009

Kamino H – Because spitzoid melanoma shares many histopathologic features with Spitz nevus, it is one of the most difficult lesions to diagnose in dermatopathology. Uncertainty exists in the medical literature about how to diagnose melanocytic proliferations including Spitz ... and spitzoid melanoma. A misdiagnosis of a melanoma as Spitz nevus is one of the most frequent causes of malpractice lawsuits in surgical pathology and dermatopathology. [more...]

Molecular pathogenesis of malignant melanoma: a different perspective from the studies of melanocytic nevus and acral melanoma
Pigment Cell & Melanoma Research, 10/19/2009

Takata M et al. – Amplifications of the cyclin D1 gene are detected in normal–looking 'field melanocytes', which represent a latent progression phase of acral melanoma that precedes ... atypical melanocyte proliferation in the epidermis. [more...]

Malignant melanoma: how error amplification by screening creates spurious disease
British Journal of Dermatology, 10/12/2009

Shuster S – The artefact of error amplification by screening detracts from a possible role for ultraviolet radiation in the increase in melanoma incidence and provides an explanation of their erroneous ... addition to melanoma, it could be a major source of misdiagnosis of other cancers associated with patient screening programmes. [more...]