Current Allergy and Asthma Reports, 05/31/2012
Zuberbier T – Chronic urticaria is defined as case of spontaneous wheals and/or angioedema persisting for a period of at least six weeks. The disease has an average duration of three to five years and is strongly associated with a decrease of quality of life and performance. Current international guidelines recommend the use of non–sedating antihistamines as the first choice in therapy and up–dosing these up to fourfold in cases of non–response. Alternative treatments for the afflicted who do not respond to antihistamine–treatment are also available but are not approved for use on urticaria.