1Multicenter, Phase II Study of Axitinib, a Selective Second-Generation Inhibitor of Vascular Endothelial Growth Factor Receptors 1, 2, 3, in Patients with Metastatic MelanomaClinical Cancer Research  Full Text  Clinical Article
2Phase I/II and Pharmacodynamic Study of Dovitinib (TKI258)-an Inhibitor of Fibroblast Growth Factor Receptors and VEGF Receptors-in Patients with Advanced MelanomaClinical Cancer Research  Full Text  Clinical Article
3Effect of vaccination with N-glycolyl GM3/VSSP vaccine by subcutaneous injection in patients with advanced cutaneous melanomaCancer Management and Research  Full Text
4Recurrence and Outcomes of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in ChildrenPediatrics  Full Text
5What determines patient preferences for treating low risk basal cell carcinoma when comparing surgery vs imiquimod? A discrete choice experiment survey from the SINS trialBMC Dermatology  Full Text  Clinical Article
6Hepatic steatosis, carotid plaques and achieving MDA in psoriatic arthritis patients starting TNF-alpha blockers treatment: a prospective studyArthritis Research & Therapy  Full Text  Clinical Article
7The treatment of melasma by silymarin creamBMC Dermatology  Full Text  Clinical Article
8Radiocontrast Media Allergic Reactions and Interventional Pain Practice - A ReviewPain Physician  Full Text
9Experiences with Surgical treatment of chronic lower limb ulcers at a Tertiary hospital in northwestern Tanzania: A prospective review of 300 casesBMC Dermatology  Full Text
10Virus Selectively Primes Human Langerhans Cells for CD70 Expression Promoting CD8+ T Cell Responses Journal of Immunology  Full Text
1Study confirms long-term benefits of melanoma immunotherapyCancer Research UK News
2Marshaling the body's own weapons against psoriasisTechnische Universit√§t M√ľnchen
3Scientists discover previously unidentified gene key to melanoma progressionCalifornia Pacific Medical Center
4Studies on skin cancer patients resistant to leading therapyThe University of Texas MD Anderson Cancer Center
5The ACR/ARHP Annual Meeting: Psoriatic arthritisThe Rheumatologist
6The ACR/ARHP Annual Meeting: Fibrotic complications of sclerodermaThe Rheumatologist
7Sunlight continues to damage skin in the darkYale School of Medicine News
8Eczema medication unlikely to increase risk of cancer in children, Penn team findsPenn Medicine
9Two cell-signaling molecules found to suppress the spread of melanomaNYU Langone Medical Center
10Possible strategy identified to combat major parasitic tropical diseaseSt. Jude Children's Research Hospital News

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Psoriasis associated with NAFLD in elderly

As reported in the Journal of the American Academy for Dermatology, non-alcoholic fatty liver disease (NAFLD) is more common in patients > 55 years of age with psoriasis. The prevalence of NAFLD in patients with and without psoriasis was 46.2% and 33.3% (OR = 1.7), respectively.

Infliximab effective in treatment of plaque-type psoriasis

As reported in the British Journal of Dermatology, of patients with plaque-type psoriasis (n=660) treated with infliximab (5 mg/kg) at weeks 0, 2, and 6, then q 8 weeks through week 50, 56.8% achieved PASI 75, 71.6% of whom maintained the response through week 98. Of patients who achieved PASI 75 by week 14, 64.7% maintained the response through week 50. Of patients who did not achieve PASI 75 by week 50, 66.3% achieved PASI 75 by week 98.

sCD40L suggests sub-clinical atherosclerosis in psoriasis

As reported in the International Journal of Dermatology, sCD40L levels are elevated and brachial artery flow-mediated dilation is decreased in patients with chronic plaque-type psoriasis (n=56) without known cardiovascular disease compared to healthy controls.

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Clinical Pearls

Clinical Pearl from Smartest DocWhen a dermatophyte is the pathogen in onychomycosis, terbinafine produces the best results.

Clinical Pearl from Smartest DocReduced vitamin D status in pregnancy may be a risk factor for the development of eczema in the first year of life.

Clinical Pearl from Smartest DocReducing oral antibiotic acne treatments to 6 months or less could lead to substantial cost savings.

The Top Read Articles of 2014 are Now Available

Scouring thousands of peer-reviewed journals and popular press, Our Editors just released the Top Read Articles of the Year. See the Top Read List