Possible association of hepatitis C virus infection with late-onset psoriasis: A hospital-based observational study

The Journal of Dermatology, 08/28/2013

Psoriasis is a chronic inflammatory disease mainly involving the skin and joints, mediated by pro–inflammatory cytokine tumor necrosis factor (TNF)–α. In hepatitis C, continuous inflammation mediated by TNF–α leads to liver cirrhosis and diabetes mellitus. Hence, psoriasis and hepatitis C have pathophysiological factors in common. HCV infection may trigger psoriasis, especially late–onset psoriasis, possibly via overproduction of TNF–α, a common mediator of the two conditions.

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