Regulatory T Cells in the Pathogenesis and Healing of Chronic Human Dermal Leishmaniasis Caused by Leishmania (Viannia) Species

PLoS Neglected Tropical Diseases, 04/26/2012

The disparity between CD25hiFoxp3+ CD4 T cell frequency in peripheral blood, Foxp3 expression at the site of cutaneous responses to leishmanin, and suppressive capacity provides evidence of impaired Treg function in the pathogenesis of CDL. Moreover, the concurrence of increased Leishmania–specific suppressive capacity with induction of a CD25hiCD127- subset of CD4 T cells during healing supports the participation of Tregs in the resolution of chronic dermal lesions.

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