Promoter methylation of aminopeptidase N/CD13 in malignant melanoma

Carcinogenesis, 04/13/2012

Staining of tissue microarrays generated from a large series of melanoma samples and control tissues demonstrated a higher APN expression in primary melanoma lesions when compared with nevi and metastases, which was neither associated with clinico–pathological parameters nor with the patients’ outcome. Thus, the heterogeneous APN expression pattern in melanoma cells is epigenetically controlled and directly associated with an altered migration capacity but not of clinical significance in the study group.

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