Duplication of CXC chemokine genes on chromosome 4q13 in a melanoma-prone family

Pigment Cell & Melanoma Research, 03/16/2012

Among them, CXCL1 (melanoma growth–stimulating activity α) and IL8 (interleukin 8) have been shown to stimulate melanoma growth in vitro and in vivo. The data suggest that the alteration of CXC chemokine genes may confer susceptibility to melanoma.

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