Safety and tolerability of an intratumorally injected DNAzyme, Dz13, in patients with nodular basal-cell carcinoma: a phase 1 first-in-human trial (DISCOVER)
The Lancet, May 8, 2013
Cho EA et al. - The nuclear transcription factor c-Jun is preferentially expressed in basal-cell carcinoma. Dz13 is a deoxyribozyme that targets JUN messenger RNA and has inhibited the growth of a range of tumours in mice. Authors did a phase 1 study to assess safety and tolerability in human beings. Dz13 was safe and well tolerated after single intratumoral injections at all doses.
Adults with nodular basal-cell carcinoma were recruited from Royal ...
Fast Evaluation of 69 Basal Cell Carcinomas With Ex Vivo Fluorescence Confocal Microscopy Criteria Description, Histopathological Correlation, and Interobserver Agreement Fast Evaluation of 69 Basal Cell Carcinomas
JAMA Dermatology, May 3, 2013
Bennàssar A et al. - This study aims to describe and validate Fluorescence confocal microscopy (FCM) criteria for the main basal cell carcinoma (BCC) subtypes and to demonstrate the overall agreement with classic pathologic analysis of hematoxylin-eosin–stained samples. The authors herein propose, describe, and validate FCM criteria for BCC diagnosis. Fluorescence confocal microscopy is an attractive alternative to histopathologic analysis of frozen sections during Mohs surgery ...
Update on non-melanoma skin cancer and the value of dermoscopy in its diagnosis and treatment monitoring
Expert Review of Anticancer Therapy, May 16, 2013
Lallas A et al. - This is because it significantly improves the early diagnosis of melanoma and non-melanoma skin cancer (NMSC) including basal cell carcinoma and keratinocyte skin cancer compared with the unaided eye. Besides its value in the noninvasive diagnosis of skin cancer, dermoscopy has also gained increased interest in the management of NMSC. Dermoscopy has been used in the preoperative evaluation of tumor margins, monitoring of the outcomes of topical treatments and ...
Lung adenocarcinoma subtypes based on expression of human airway basal cell genes
European Respiratory Journal , May 6, 2013
Fukui T et al. - The study explores whether a subtype of lung adenoCa expresses the unique molecular features of human airway basal cell (BC), and how expression of the airway BC features correlates with the molecular, pathologic and clinical phenotype of lung lung adenocarcinoma (adenoCa). Activation of the airway BC program is a molecular feature of a distinct, aggressive subtype of lung adenoCa.
Recurrent lentigo maligna melanoma commingling the tumour nests of a basal cell carcinoma
Journal of Plastic, Reconstructive & Aesthetic Surgery, May 3, 2013
Hassan Z et al. - In this report the authors describe a case of basal cell carcinoma (BCC) colonised by recurrent lentigo maligna melanoma. The case appears to be unique, in that it was a recurrent lentigo maligna melanoma which was colonising the BCC. They treated the patient with wide local excision and full thickness skin graft and will continue to observe him on an outpatient basis. There needs to be long term follow up of a larger number of patients for us to truly appreciate the ...
Photodynamic therapy versus topical imiquimod versus topical fluorouracil for treatment of superficial basal-cell carcinoma: a single blind, non-inferiority, randomised controlled trial
The Lancet Oncology, May 16, 2013
Arits AHMM et al. - Topical fluorouracil was non-inferior and imiquimod was superior to MAL-PDT for treatment of superficial basal-cell carcinoma. On the basis of these findings, imiquimod can be considered the preferred treatment, but all aspects affecting treatment choice should be weighted to select the best treatment for patients. Methods In this single blind, non-inferiority, randomised controlled multicentre trial, we enrolled patients with a histologically proven superficial ...
Cdc42 is involved in basal cell carcinoma carcinogenesis
Archives of Dermatological Research, April 30, 2013
Tucci MG et al. - This study aims to investigate E-cadherin-dependent cell–cell contacts and Cdc42 activity in BCC formation. This study also showed that Cdc42 and E-cadherin expression differed according to aggressive behaviour of BCC subtypes and suggested important functions of these molecules in regulating tumour demarcation and progression.
Risk of subsequent cutaneous malignancy in patients with prior keratinocyte carcinoma: A systematic review and meta-analysis
European Journal of Cancer, May 10, 2013
Flohil SC et al. - In this systematic review and meta-analysis the risk of a subsequent basal cell carcinoma (BCC), squamous cell carcinoma (SCC) or melanoma in patients with a previous keratinocyte carcinoma (KC) was investigated. The pooled SIRs for a subsequent BCC, SCC or melanoma were respectively 17.4 (95% CI 0.0–37.4), 3.2 (0.0–6.5) and 2.4 (2.3–2.6) in BCC and 4.2 (95% CI 2.0–6.5), 15.0 (14.0–16.0) and 2.7 (2.3–3.2) in SCC patients. In the subgroup analyses, strongest ...
Thickness of superficial basal cell carcinoma predicts imiquimod efficacy, a proposal for thickness-based definition of superficial basal cell carcinoma
British Journal of Dermatology, May 2, 2013
McKay KM et al. - This study aims to determine whether tumour thickness in superficial BCC (sBCC) is a predictor of treatment failure. The authors recommend the use of tumor thickness to define superficial pattern in pathology reports for BCC as this can help to determine treatment response of sBCC to imiquimod.
Role of NF-kB in the pathogenesis of psoriasis elucidated by its staining in skin biopsy specimens
International Journal of Dermatology, May 3, 2013
Moorchung N et al. - NF-kB is a transcription factor belonging to the Re1 family, and it regulates the activity of a large number of proinflammatory genes. Its role in psoriasis, which is a prototype chronic inflammatory disease, is therefore expected to be considerable. It has been found that many of the triggering factors for psoriasis initiate inflammation by activation of NF-kB. The study has demonstrated that translocation of NF-kB in the epidermis and basal cells ...