DCL1 is a tumor suppressor in melanoma patients
As reported in Modern Pathology, down-regulation of cytoplasmic and nuclear DLC1 is associated with poor overall survival and disease-specific 5-y survival in all melanoma patients. Combined down-regulation of cytoplasmic and nuclear DCL1 was associated with the worse survival for patients with metastatic melanoma.
Pantothenic acid effective for acne
As reported in Dermatology and Therapy, a pantothenic acid-based dietary supplement for 12 weeks reduced the total lesion count, number of inflammatory lesions, and DLQI in patients with mild-to-moderate acne (n=41) compared to placebo.
Infliximab effective in treatment of plaque-type psoriasis
As reported in the British Journal of Dermatology, of patients with plaque-type psoriasis (n=660) treated with infliximab (5 mg/kg) at weeks 0, 2, and 6, then q 8 weeks through week 50, 56.8% achieved PASI 75, 71.6% of whom maintained the response through week 98. Of patients who achieved PASI 75 by week 14, 64.7% maintained the response through week 50. Of patients who did not achieve PASI 75 by week 50, 66.3% achieved PASI 75 by week 98.