Toll-Like Receptor 2 Knockdown Modulates Interleukin (IL)-6 and IL-8 but not Stromal Derived Factor-1 (SDF-1/CXCL12) in Human Periodontal Ligament and Gingival Fibroblasts

Journal of Periodontology, 06/11/2012

The results suggest that signaling through TLR2 by gingival and periodontal ligament fibroblasts can control the secretion of IL–6 and IL–8, which contribute to periodontal pathogenesis, but do not interfere with CXCL12 levels, an important chemokine in the repair process.

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