The periodontium of periodontitis patients contains citrullinated proteins which may play a role in ACPA (anti citrullinated protein antibody) formation
Journal of Clinical Periodontology, 05/02/2012Nesse W et al.
Within the periodontal stroma, citrullination is an inflammation–depended process. In periodontal epithelium, citrullination is a physiological process. Additional citrullinated proteins are formed in periodontitis, apparently similar to those formed in RA–affected synovial tissue. Periodontitis induced citrullination may play a role in the aetiology of rheumatoid arthritis.
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