Cell proliferation and apoptosis in the fusion of human primary and secondary palates
European Journal of Oral Sciences, 06/26/2012
Vukojevic K et al. – The study indicates similar principles for human primary palate and secondary palate fusion, and parallel persistence of proliferation and apoptotic activity. While proliferation enables growth and fusion of different palatal primordia, apoptosis results in the removal of of large numbers epithelial cells at the fusion point. The disintegration of seam remnants seems to be executed through the processes of change in protein content and cell migration, probably leading to cell death as their final outcome.