Changes in Inflammatory and Metabolic Parameters After Periodontal Treatment in Obese and Non-Obese Patients
Journal of Periodontology, 02/23/2012
Exclusive author commentary
Gurgan CA et al. – The non–surgical periodontal treatment causes a decrease in the levels of some circulating proinflammatory cytokines and maybe associated with a decrease in insulin resistance in the obese population.
Cem A. Gurgan (02/26/2012) comments:
Dear editor, Below, please find our comments on the findings of our study. Regards Cem A. GURGAN On be half of the authors The main findings of the study was the non-surgical periodontal treatment causes a decrease in the levels of some circulating proinflammatory cytokines and maybe associated with a decrease in insulin resistance in the obese population who do not lose weight. This finding was surprising since lipid profiles, body mass indexes and their hsCRP levels of the obese patients were similar before and 3 months after periodontal treatment. The classical approaches aiming to treat insulin resistance are focused on mechanisms involving the liver, skeletal muscle or adipose tissue. However, in our study the functions of all these three organs were unchanged. The only changing parameter was the alleviation of local chronic inflammation (periodontitis). This may suggest an indirect role of macrophages, the key members of chronic inflammation, in insulin resistance. Cem A GURGAN, Umut ALTAY and Kemal A?BAHT