New form of administering chlorhexidine for treatment of denture-induced stomatitis Full Text
Therapeutics and Clinical Risk Management, 06/17/2011
Ryalat S et al. – The findings of this study support the use of chlorhexidine–impregnated self–cured PMMA chair–side resin as a new dosage form for the treatment of denture–induced stomatitis.Methods
- Release of chlorhexidine was evaluated using liquid chromatography, and the effect of the drug on the growth of C. albicans was investigated microbiologically using a “well” technique on Saboraud culture medium inoculated with a resistant strain of C. albicans.
- Chlorhexidine leached steadily out of the acrylic resin into distilled water at mouth temperature, and the sustained drug release continued throughout the 28–day test period.
- The drug released also demonstrated antifungal activity against the resistant strain of C. albicans.