Impact of dental care in the prevention of bisphosphonate-associated osteonecrosis of the jaw: a single-center clinical experience
Annals of Oncology, 04/06/2011
Vandone AM et al. – In comparison with published Osteonecrosis of the jaw (ONJ) rates and those extrapolated from the retrospective analysis, the observed ONJ rate in the prospective group was lower, suggesting that implementation of a preventive dental program may reduce the risk of ONJ in metastatic patients treated with i.v. BP therapy.
This prospective single-center study included patients with bone metastases from solid tumors
Patients who received at least one BP infusion between October 2005 and 31 August 2009 underwent one or more ICG evaluation and regular dental examinations
Evaluated patients with bone metastases from solid tumors who did not undergo dental preventive measures.
Of 269 patients, 211 had received at least one infusion of BP therapy
62% were BP naive and 38% had previous BP exposure
Of these 211 patients followed for 47 months, 6 patients developed ONJ (2.8%)
Of 200 patients included in the retrospective analysis, 11 patients developed ONJ (5.5%)
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