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Evaluation of the Cytotoxic and Genotoxic Effects of Orthodontic Bonding Adhesives upon Human Gingival Papillae through Immunohistochemical Expression of p53, p63 and p16
Anticancer Research, 11/10/09
Angiero F et al. – The significance of p53, p63 and p16 positivity, and whether these proteins may serve as biomarkers to predict the risk of developing oral lesions (dysplasia, oral cancer) is still unclear. Although details of the mechanisms leading to cell death, genotoxicity and cell–cycle delay are not fully understood, resin monomers may alter cell function in the oral cavity.
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