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Mishra A et al. – The overexpression of EGFR mRNA, p50:p50/NF–kappaB homodimer formation, together with overexpression of pERK and c–Fos proteins in this study suggests an interesting cross talk between AP–1 and NF–kappaB pathways in oral cancers. Thus, this study demonstrates differential expression and activation of AP–1 super–family proteins in relation to severity of lesion and their crucial role in human oral carcinogenesis.


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