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See Latest ArticlesGene Clustering Analysis in Human Osseous Remodeling
Journal of Periodontology, 10/09/09
Sbordone L et al. – A de novo identification based on the data mining of leader genes involved in bone–volume augmentation or bone remodeling, in order to acquire primeval information about their molecular basis and to plan future ad hoc targeted experiments, was performed. For several genes of the upper clusters, an active role in bone processes was already known, but the present analysis suggests that they play a major role in the analyzed phenomena. The role of the transcription factors as leader genes and the numerous “orphan genes” (genes with WNL = 0) recovered probably attests to a lack of information regarding these processes, which could be further clarified through further specific DNA microarray experiments.
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