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Analysis of matrix metalloproteinase (MMP-8 and MMP-2) activity in gingival crevicular fluid from children with Downs syndrome
Journal of Periodontal Research, 09/30/09

Yamazaki–Kubota T et al. – High levels of colonization by periodontopathic bacteria and a high prevalence of chronic inflammatory periodontal disease have been reported in children with Down's syndrome. Matrix metalloproteinases (MMPs) are mediators of extracellular matrix degradation and remodelling, and are deeply involved in the course of periodontal disease. The results suggest an increase in MMP–2 and MMP–8 in Down's syndrome patients, regardless of whether inflammation of periodontal tissue is present or not.

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