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The Anti-inflammatory Role of Heme Oxygenase-1 in Lipopolysaccharide and Cytokine-Induced Inducible Nitric Oxide Synthase and Nitric Oxide Production in Human Periodontal Ligament Cells
Journal of Periodontology, 09/04/09
Kim Y–S et al. – Collectively, these data suggest that HO–1 inhibition blocked LPS– and proinflammatory cytokines–induced iNOS expression and NO production in PDL cells via a mechanism that involves p38, ERK, PI3K, NF–kappaB and PKC delta. Thus, regulation of HO–1 activity may be a therapeutic strategy for periodontal disease.
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