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See Latest ArticlesA Randomized, Controlled, Dose-ranging Study Investigating Single Doses of GW406381, Naproxen Sodium, or Placebo in Patients With Acute Pain After Third Molar Tooth Extraction
The Clinical Journal of Pain, 08/21/09
Varner J et al. – Pain relief intensity differences from placebo were statistically significant beginning at 1.5 hours postdosing for GW406381 70 and 50 mg and at 2–hour postdosing for GW406381 25 and 10 mg. The median time to onset of analgesia was 71 minutes for GW406381 50 mg, 72 minutes for GW406381 70 mg, and 36 minutes for naproxen. The median duration of analgesia was 5.9 hours for GW406381 50 mg, 7.9 hours for GW406391 70 mg, and 11.3 hours for naproxen. All treatments were well tolerated. GW406381 50 and 70 mg demonstrated clinically meaningful analgesia in this acute pain setting, although the onset of analgesia was greater than 1 hour.
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