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Regulatory roles of beta-catenin and AP-1 on osteoprotegerin production in interleukin-1alpha-stimulated periodontal ligament cells
Oral Microbiology and Immunology, 08/20/09
Suda T et al. – The present study suggests that beta–catenin enhances IL–1alpha–induced OPG production in both PDL cells and hGFs, whereas AP–1 suppresses IL–1alpha–induced OPG production in PDL cells. Higher expression of c–fos in PDL cells than in hGFs may implicate a role of PDL cells in alveolar bone resorption in periodontitis.
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