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Hao Y et al. – Caspase–3 activity increased in proportion to the magnitude of the stretching force, and this effect was reduced significantly by a caspase–9 inhibitor, whereas a caspase–8 inhibitor had no such effect. The authors concluded that the in vitro application of cyclic stretching force can induce apoptosis in PDL cells by activating the caspase–3 via the caspase–9 signalling cascade. The findings may provide a novel insight into the mechanism of apoptosis induced by stretching force in PDL cells.

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