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Castells A et al. – The review focuses specifically on this group of nonsyndromic familial CRC, dissecting its genetic background, unveiling the most efficient screening strategies, and revealing potential therapeutic implications. Because of the evolving definition and dynamic nature of this entity, most aspects of this review should be considered temporary; after gaining insight into the molecular basis of familial CRC, new predisposing syndromes will be identified, thereby narrowing the amalgam of patients belonging to the familial CRC category.

   

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