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Vascular and Psychophysical Effects of Topical Capsaicin Application to Orofacial Tissues
Journal of Orofacial Pain, 07/27/09

Boudreau SA et al. – Compared to vehicle application, capsaicin elicited burning pain, increases in blood flow and temperature, but no change in mechanical sensitivity in the glabrous lips or tongue. Greater increases in blood flow and temperature paralleled more intense burning pain and larger areas of perceived pain for the lips compared to the tongue. The location of distinct areas of increased temperature within the orofacial area differed between the capsaicin–lip and capsaicin–tongue trials. The several differences between these responses to noxious stimulation of the glabrous lips and tongue may have implications for examinations of orofacial somatosensory functions.

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