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Alcohol intake and oral cavity cancer risk among men in a prospective study in Kerala, India
Community Dentistry and Oral Epidemiology, 07/16/09
Cancela MC et al. – Study reports that alcohol intake plays an important role in oral carcinogenesis, and understanding this role is relevant to developing public health policies targeting at-risk population.
Methods- An evaluation of the role of alcohol drinking and patterns of consumption in oral cancer incidence and mortality in a cohort study using data from Trivandrum Oral Cancer Screening Study, India
- Lifestyle questionnaire included items on frequency and duration of alcohol consumption
- They were followed up for oral cancer incidence and mortality
- Data from 32,347 subjects, of whom 134 eventually developed oral cancer, were analysed to estimate risk of oral cancer incidence and mortality according to drinking patterns
- Cox regression model adjusted for age, religion, education, occupation, BMI, standard of living index, chewing habits, smoking habits, and vegetable and fruit intake was used
- Current and past drinkers were each associated with increased risk of developing oral cancer
- The hazard ratio increased by 49% among current drinkers and 90% among past drinkers
- A dose-response relationship between intake frequency, duration and oral cancer risk was observed
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