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Nickel-based (Ni–Cr and Ni–Cr–Be) alloys used in dental restorations may be a potential cause for immune-mediated hypersensitivity
Medical Hypotheses, 06/04/09
Lu Y et al. - The metal surface would occur electrochemical corrosion as metal edge of porcelain-fused-to-nichrome crown exposed to oral cavity rich in electrolytes after restoration, and metal ion would release to oral cavity then come into contact with cells and tissues in the immediate environment, or be distributed throughout the body, mainly to the intestine canal. It is necessary to determine the long-term biocompatibility properties of nickel-based alloy, reduce sensitization, and grasp the information of individual differences in the appearance of adverse reactions in further research.
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