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Simvastatin as a Novel Strategy To Alleviate Periapical Lesions
Journal of Endodontics, 05/21/09
Lin SK et al. - The numbers of Cyr61-synthesizing osteoblasts and CD-68–positive macrophages were also decreased. Simvastatin suppresses the progression of apical periodontitis, possibly by diminishing Cyr61 expression in osteoblasts and, subsequently, macrophage chemotaxis into the lesions.
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