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See Latest ArticlesEmerging Peripheral Receptor Targets for Deep-tissue Craniofacial Pain Therapies
Journal of Dental Research , 04/07/09
Ambalavanar R et al. - P2X3, TRPV1, and ASIC3 are often co-expressed in trigeminal neurons, implying the formation of functional complexes that allow craniofacial nociceptive neurons to respond synergistically to altered ATP and pH in pain. Future therapeutics for craniofacial pain thus might be more efficacious if targeted at combinations of P2X3, CGRP, TRPV1, and ASIC3.
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