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Expression of Mcm2, geminin, and Ki67 in normal oral mucosa, oral epithelial dysplasias and their corresponding squamous-cell carcinomas
British Journal of Cancer, 03/31/09

Torres-Rendon A et al. - In a study to identify the expression pattern of minichromosome maintenance protein 2 (Mcm2), Ki67, and geminin in normal oral mucosa (NOM), oral epithelial dysplasia (OED), and their subsequent oral squamous-cell carcinoma (OSCC), to determine if expression could predict the prognosis of OED, it was found that Mcm2 and geminin proteins seem to be novel biomarkers of growth and may be useful prognostic tools for OED.

Methods

Paraffin sections of 41 OED cases that progressed to carcinoma, 40 OED without malignant progression, 38 OSCC, and 15 NOM were immunostained with antibodies against Mcm2, geminin, and Ki67.

Results

Labelling indices (LIs) increased progressively from NOM, OED, and OSCC.
In all the OED cases (n=81), levels of expression of Mcm2 (LI, 73.6), geminin (LI, 24.4), and Ki67 (LI, 44.5) were elevated indicating a constant cell-cycle re-entry.
When the OED groups were compared, Mcm2 protein expression was higher in the OED with malignant progression, likewise there was a significant increase in the Mcm2/Ki67 and geminin/Ki67 ratios.

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