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Singh DP et al. - This study showed that there was a statistically significant difference in salivary nickel and chromium concentrations before and 1 week and 3 weeks after insertion of fixed orthodontic appliances. The highest concentrations of nickel and chromium were found after 1 week. The salivary nickel and chromium concentrations tapered off 3 weeks after insertion but were significantly higher than baseline levels.

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