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p16 promoter methylation is a potential predictor of malignant transformation in oral epithelial dysplasia
Cancer Epidemiology, Biomarkers & Prevention, 08/20/08

Hall GL et al. - In a trial to explore the prognostic value of a previously validated panel of methylation biomarkers in a cohort of pts with histologically proven oral dysplasia, it seems that methylation of the p16 gene promoter shows promise as a predictor for malignant transformation in a subset of pts

• This study uses longitudinal clinical samples to explore the prognostic value of a previously validated panel of methylation biomarkers in pts with histologically proven oral dysplasia
• Methylation enrichment pyrosequencing assays were used to provide the sensitivity of traditional methylation-specific PCR with the additional specificity advantages of a subsequent confirmatory sequencing reaction

• In 57% of pts with a lesion that transformed to oral squamous cell carcinoma, 26% of longitudinal samples collected over 3 years showed p16 methylation
• Only 1% of samples from 8% of pts not undergoing malignant transformation within 3 years had p16 methylation
• Both of these samples with p16 promoter methylation were the most recently collected and the pts remain under continuing clinical review
• Promoter methylation of MGMT, CYGB, and CCNA1 did not correlate with malignant progression

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