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Anaplastic large cell lymphoma in gingiva
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, 08/08/08

Matsumoto N et al. - Immunohistochemical analysis of the proliferating cells revealed positivity for CD30 and T-cell markers, such as CD45RB, as well as CD45RO antibodies, and they were weakly positive for the granzyme B antibody. In contrast, the tumor cells were negative for all B-cell markers as well as for CD3, CD56, S-100 protein, epithelial membrane antigen, and p80NPM/ALK antibodies. Based on the clinical and histopathologic features, the lesion was diagnosed as an ALCL in both the upper and the lower gingiva. This is an extremely rare case, in which a specific subtype of T-cell lymphoma appeared in the oral cavity.

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