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Huang, G.T., et al. - To localize ex vivo expression of interleukin-8 (IL-8) induced by substance P (SP) in human dental pulps...Substance P induces IL-8 expression and was located in fibroblast-like pulp cells, blood vessel-associated cells and extracellular matrix of human dental explants. These data support the hypothesis that neuropeptide (SP) coordinates the modulation of pulpal inflammation via up-regulating chemokine IL-8

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