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Takahashi, M., et al. - The purpose of this study was to investigate cusp size variability in the human permanent maxillary first and second molars, with particular reference to the hypocone...Several hypotheses relating to cuspal variation within and between M1 and M2 were tested using Chi-square tests, t-tests and ANOVA...Findings are consistent with the view that phenotypic variability within maxillary molar crowns is generated by dynamic interactions between developing cusps that form at different times and grow at different rates for different durations

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