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Duarte, P., et al. - This study evaluated whether diabetes modulates gene expression in sites with periodontitis.Gingival biopsies were harvested and divided into three groups – Control group: systemically and periodontally healthy subjects; Periodontitis group: systemically healthy subjects diagnosed with chronic periodontitis; Diabetes group: type 1 diabetic subjects, diagnosed with chronic periodontitis. Total RNA was obtained and analyzed by quantitative polymerase chain reaction. The results suggest that decreased levels of IL-10 and OPG may play an important role in the periodontal breakdown in diabetic patients

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