The effect of using an alternative irrigant between sodium hypochlorite and chlorhexidine to prevent the formation of para-chloroaniline within the root canal system.

International Endodontic Journal, 03/23/2012

Citric acid used as the intermittent irrigant had the least amount of para–chloroaniline (PCA) formation in the canal system. Until the threshold required to cause biological damage in humans is determined, the combination of NaOCl and CHX in root canal treatment should be avoided.

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