Controversy of proton pump inhibitor and clopidogrel interaction: A review
Journal of Digestive Diseases,  Clinical Article

Tan HJ – Proton pump inhibitor is often co–prescribed with clopidogrel to reduce the gastrointestinal risk of bleeding ulcer in patients following acute coronary syndrome or stent implant. However, the safety issue of such practice has been scrutinised after some studies reporting an increase incidence of cardiovascular events and mortality, although there were also researchers reporting otherwise. This has lead to the warning statement from the US Food and Drug Administration FDA cautioning the concomitant use of proton pump inhibitor and clopidogrel. This review examines the evidence of proton pump inhibitor as gastroprotective agent, H2RA as an alternative therapy, the influence of proton pump inhibitor on the antiplatelet effect of clopidogrel, and the controversies of various studies.

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

    Currently, there are no available articles.

Your Unread Messages in Cardiology

See All >> Messages include industry-sponsored communications and special communications from MDLinx


Most Popular Cardiology Articles

Indexed Journals in Cardiology: American Heart Journal, American Journal of Cardiology, Circulationn, Heartmore


The Top Read Articles of 2014 are Now Available

Scouring thousands of peer-reviewed journals and popular press, Our Editors just released the Top Read Articles of the Year. See the Top Read List