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Cardiology - Basic Science/Genetics News & Articles
MDLinx Cardiology – on this page: Articles from over 2,000 of the peer-reviewed medical journals, pre-sorted and ranked by what’s most relevant to your day-to-day practice, and summarized to save you precious time. From vascular disorders and stroke to valvular disorders, coronary artery disease and arrhythmias, our physician editors make sure that all members of your heart health team can be current on the literature in 5 minutes or less every day.
Also on this page: Bonus content exclusive to MDLinx, clinical pearls from The Smartest Cardiologist daily quiz competition and Cardiology Physician Review. Plus, the “must-read” articles related to cardiology, personally chosen by our physician editor, D. Scott Cunningham, MD, PhD.
Your Unread Messages in Cardiology
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Articles
Latest (1) Full Text Articles (324) Focus on MI501 Genetic lecithin:cholesterol acyltransferase deficiency and cardiovascular disease Atherosclerosis, June 12, 2012
502 The magic and mystery of MicroRNA-27 in atherosclerosis Atherosclerosis, June 12, 2012
503 A classical phenotype of anderson-fabry disease in a female patient with intronic mutations of the gla gene: a case report BMC Cardiovascular Disorders, June 11, 2012
504 Osteocalcin transforms vascular fibroblasts to myofibroblasts via angiotensin ii and toll-like receptor 4 Circulation Research, June 8, 2012
505 A novel missense mutation causing a G487R substitution in the S2-S3 loop of human ether-a-go-go-related gene channel Journal of Cardiovascular Electrophysiology, June 6, 2012
506 Expression and functional significance of NADPH oxidase 5 (Nox5) and its splice variants in human blood vessels American Journal of Physiology - Heart and Circulatory Physiology, June 6, 2012
507 RNA-binding protein RBM24 is required for sarcomere assembly and heart contractility Full Text Cardiovascular Research, June 6, 2012
508 Monocyte chemotactic protein 3 is a homing factor for circulating angiogenic cells Full Text Cardiovascular Research, June 6, 2012
509 The GRAF family member oligophrenin1 is a RhoGAP with BAR domain and regulates Rho GTPases in platelets Full Text Cardiovascular Research, June 6, 2012
510 Theoretical comparison of wall-derived and erythrocyte-derived mechanisms for metabolic flow regulation in heterogeneous microvascular networks American Journal of Physiology - Heart and Circulatory Physiology, June 5, 2012
511 The multifunctional Ca2+/calmodulin-dependent kinase II regulates vascular smooth muscle migration through matrix metalloproteinase 9 American Journal of Physiology - Heart and Circulatory Physiology, June 5, 2012
512 Mechanotransduction through fibronectin-integrin focal adhesion in microvascular smooth muscle cells: is calcium essential? American Journal of Physiology - Heart and Circulatory Physiology, June 5, 2012
513 Deletion of discoidin domain receptor 2 does not affect smooth muscle cell adhesion, migration, or proliferation in response to type I collagen Cardiovascular Pathology, June 4, 2012
514 An update on the genetics of pheochromocytoma Journal of Human Hypertension, June 4, 2012
515 Genetically elevated levels of circulating triglycerides and brachial-ankle pulse wave velocity in a Chinese population Journal of Human Hypertension, June 4, 2012
516 Recessively inherited severe aortic aneurysm caused by mutated efemp2 The American Journal of Cardiology, June 1, 2012
517 Apex1 regulation of aldosterone synthase gene transcription is disrupted by a common polymorphism in humans Circulation Research, June 1, 2012
518 Mapk phosphorylation of connexin 43 promotes binding of cyclin e and smooth muscle cell proliferation Circulation Research, June 1, 2012
519 A nonsense variation p.Arg325X in the vascular endothelial growth factor-A gene may be associated with congenital tricuspid aortic valve stenosis Cardiology in the Young, May 31, 2012
520 Atypical protein kinase C in cardiometabolic abnormalities Current Opinion in Lipidology, May 30, 2012
Clinical Pearls in Cardiology
- Intracoronary abciximab when compared to intravenous abciximab significantly reduces the risk of death among patients with STEMI undergoing PCI
- Thrombolysis in MI (TIMI) scores between 5-14 on admission place patients at high risk for 30-day mortality and should be transferred to a monitored inpatient unit or CCU
- High-sensitivity cardiac troponin T is superior to contemporary sensitive cardiac troponin I in early diagnosis of non-STEMI and the prediction of MI and mortality among patients with suspected ACS
Highlights in Cardiology
Heart failure risk associated with adiponectin level
As published in Obesity, a J-shaped association between adiponectin level and heart failure exists. The study involved 787 males with heart failure and 787 healthy controls from the Physicians’ Health Study. The relative risk of heart failure from lowest to highest quintile of adiponectin level was 0.74, 0.67, 0.70, and 0.92.
Read the article summaryApo B-48 is a marker for CAD
As published in the European Journal of Clinical Investigation, fasting serum apo B-48 levels were elevated in patients with Coronary Artery Disease (n=96; 6.9 µg/mL) compared to patients without CAD (n=67; 3.9 µg/mL). Along with other cardiac risk factors, an apo B-48 level > 4.34 µg/mL was predictive of CAD.
Read the article summaryPost-exercise heart rate recovery predicts cardiac autonomic neuropathy in T2DM
As published in Diabetic Medicine, cardiac autonomic neuropathy can be predicted in patients with T2DM and negative exercise echocardiograms based on post-exercise heart rate recovery. Of the 135 study subjects, 27 (20%) had cardiac autonomic neuropathy, the criteria for which included > 2 of 7 autonomic function markers (4 cardiac reflex tests and 3 indices of short-term heart rate variability). The optimal cut-offs for post-exercise heart rate recovery at 1-, 2-, and 3-minutes were < 28, < 50, and < 52 beats per minute, respectively.
Read the article summaryMost Popular Cardiology Articles
Last month's top read Top Articles of 20121 Outcomes of apixaban vs. warfarin by type and duration of atrial fibrillation: results from the ARISTOTLE trial European Heart Journal, April 22, 2013
2 Comparison of Double Kissing Crush Versus Culotte Stenting for Unprotected Distal Left Main Bifurcation Lesions : Results From a Multicenter, Randomized, Prospective DKCRUSH-III Study JACC - Journal of the American College of Cardiology, April 2, 2013
3 Rate versus rhythm control for management of atrial fibrillation in clinical practice: Results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry American Heart Journal, April 1, 2013
4 Effect of longer term modest salt reduction on blood pressure: Cochrane systematic review and meta-analysis of randomised trials British Medical Journal, April 25, 2013 Evidence Based Medicine Review Article
5 Role of exercise in the prevention of cardiovascular disease: results, mechanisms, and new perspectives European Heart Journal, April 11, 2013
6 Effect of Metoprolol Versus Carvedilol on Outcomes in MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy) JACC - Journal of the American College of Cardiology, April 3, 2013
7 Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial The Lancet, April 18, 2013
8 Atrial fibrillation-induced cardiac troponin I release International Journal of Cardiology, April 29, 2013
9 L-Carnitine in the Secondary Prevention of Cardiovascular Disease: Systematic Review and Meta-analysis Mayo Clinic Proceedings, April 19, 2013 Evidence Based Medicine Review Article
10 Effect of seven-day atorvastatin pretreatment on the incidence of periprocedural myocardial infarction following percutaneous coronary intervention in patients receiving long-term statin therapy. A randomized study International Journal of Cardiology, April 19, 2013
11 Discovery and Characterization of Alamandine Circulation Research, April 15, 2013
12 Perioperative Dexmedetomidine Improves Outcomes of Cardiac Surgery Circulation, April 24, 2013
13 Effect of Morbid Obesity on In-Hospital Mortality and Coronary Revascularization Outcomes After Acute Myocardial Infarction in the United States The American Journal of Cardiology, April 5, 2013
14 Home-based versus hospital-based high-intensity interval training in cardiac rehabilitation: a randomized study European Journal of Preventive Cardiology, April 25, 2013
15 Long-term clinical follow-up of the multicenter, randomized study to test immunosuppressive therapy with oral prednisone for the prevention of restenosis after percutaneous coronary interventions: Cortisone plus BMS or DES veRsus BMS alone to EliminAte Restenosis (CEREA-DES) European Heart Journal, April 11, 2013
16 Left Ventricular Diastolic Dysfunction in Patients With Mitral Stenosis Undergoing Percutaneous Mitral Balloon Valvotomy Mayo Clinic Proceedings, April 9, 2013
17 Reduction of Stent Thrombosis in Patients with Acute Coronary Syndrome Treated with Rivaroxaban in ATLAS ACS 2-TIMI 51 JACC - Journal of the American College of Cardiology, April 26, 2013
18 Outcome of Combined Stenotic and Regurgitant Aortic Valve Disease JACC - Journal of the American College of Cardiology, April 4, 2013
19 Enalapril And Carvedilol for Preventing Chemotherapy-Induced Left Ventricular Systolic Dysfunction in Patients with Malignant Hemopathies. The OVERCOME Trial JACC - Journal of the American College of Cardiology, April 12, 2013
20 Efficacy and safety of dabigatran etexilate and warfarin in real world patients with atrial fibrillation: A prospective nationwide cohort study JACC - Journal of the American College of Cardiology, April 15, 2013
Indexed Journals in Cardiology: American Heart Journal, American Journal of Cardiology, Circulationn, Heart more
Other Topics in Cardiology
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