MDLinx Cardiology – on this page: Articles from over 2,000 of the peer-reviewed medical journals, pre-sorted and ranked by what’s most relevant to your day-to-day practice, and summarized to save you precious time. From vascular disorders and stroke to valvular disorders, coronary artery disease and arrhythmias, our physician editors make sure that all members of your heart health team can be current on the literature in 5 minutes or less every day.
Also on this page: Bonus content exclusive to MDLinx, clinical pearls from The Smartest Cardiologist daily quiz competition and Cardiology Physician Review. Plus, the “must-read” articles related to cardiology, personally chosen by our physician editor, D. Scott Cunningham, MD, PhD.
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941 The Influence of Smoking Status on the Pharmacokinetics and Pharmacodynamics of Clopidogrel and Prasugrel: The PARADOX Study JACC - Journal of the American College of Cardiology, April 25, 2013 Clinical Article
942 Genetics of HDL-C: A Causal Link to Atherosclerosis? Current Atherosclerosis Reports, April 25, 2013 Review Article
943 Long-term effects of low-fat diets either low or high in protein on cardiovascular and metabolic risk factors: a systematic review and meta-analysis Full Text Nutrition Journal, April 25, 2013 Evidence Based Medicine Review Article
944 SHBG and endothelial function in older subjects International Journal of Cardiology, April 25, 2013 Clinical Article
945 Effects of high dose intravenous fish oil on human atrial electrophysiology: Implications for possible anti- and pro-arrhythmic mechanisms in atrial fibrillation International Journal of Cardiology, April 25, 2013 Clinical Article
946 Long-term outcome of enzyme-replacement therapy in advanced Fabry disease: evidence for disease progression towards serious complications Journal of Internal Medicine, April 25, 2013 Evidence Based Medicine Clinical Article
947 Comprehensive Approach to Lower Blood Pressure (CALM-BP): a randomized controlled trial of a multifactorial lifestyle interventionOpen Journal of Human Hypertension, April 25, 2013 Clinical Article
948 Expanding the Evidence Base: Comparing Randomized Controlled Trials and Observational Studies of Statins American Journal of Therapeutics, April 25, 2013 Evidence Based Medicine Review Article Clinical Article
949 Cardiac MRI scar patterns differ by sex in an implantable cardioverter-defibrillator and cardiac resynchronization therapy cohort Heart Rhythm, April 25, 2013 Clinical Article
950 Comparison of Factors Associated with Carotid Intima-Media Thickness in the Multi-Ethnic Study of Atherosclerosis (MESA) and the Heinz Nixdorf Recall Study (HNR) Journal of the American Society of Echocardiography, April 25, 2013 Clinical Article
951 Localized Transvalvular Pressure Gradients in Mitral Bileaflet Mechanical Heart Valves and Impact on Gradient Overestimation by Doppler Journal of the American Society of Echocardiography, April 25, 2013 Clinical Article
952 Comprehensive Analysis of Left Ventricular Geometry and Function by Three-Dimensional Echocardiography in Healthy Adults Journal of the American Society of Echocardiography, April 25, 2013 Clinical Article
953 Apical ventricular tachycardia morphology in left ventricular nonischemic cardiomyopathy predicts poor transplant-free survival Heart Rhythm, April 25, 2013 Clinical Article
954 Association between sleep duration and blood pressure in adolescents Hypertension Research, April 25, 2013 Clinical Article
955 Simultaneous assessment of endothelial function and morphology in the brachial artery using a new semiautomatic ultrasound system Hypertension Research, April 25, 2013 Clinical Article
956 The associations of high birth weight with blood pressure and hypertension in later life: a systematic review and meta-analysis Hypertension Research, April 25, 2013 Evidence Based Medicine Review Article
957 Failure rate of the Riata lead under advisory: A report from the CHRS Device Committee Heart Rhythm, April 25, 2013 Clinical Article
958 Pericardial cytokines in neoplastic, autoreactive, and viral pericarditis Heart Failure Reviews, April 25, 2013 Clinical Article
959 Cardiovascular function in children born very preterm after intrauterine growth restriction with severely abnormal umbilical artery blood flow European Journal of Preventive Cardiology, April 25, 2013 Clinical Article
960
Demonstration of posterior fascicle to myocardial conduction block during ablation of idiopathic left ventricular tachycardia: An electrophysiological predictor of long-term success
Heart Rhythm, April 25, 2013
Clinical Article
Exclusive Author Commentary
As published in Obesity, a J-shaped association between adiponectin level and heart failure exists. The study involved 787 males with heart failure and 787 healthy controls from the Physicians’ Health Study. The relative risk of heart failure from lowest to highest quintile of adiponectin level was 0.74, 0.67, 0.70, and 0.92.
Read the article summaryAs published in the European Journal of Clinical Investigation, fasting serum apo B-48 levels were elevated in patients with Coronary Artery Disease (n=96; 6.9 µg/mL) compared to patients without CAD (n=67; 3.9 µg/mL). Along with other cardiac risk factors, an apo B-48 level > 4.34 µg/mL was predictive of CAD.
Read the article summaryAs published in Diabetic Medicine, cardiac autonomic neuropathy can be predicted in patients with T2DM and negative exercise echocardiograms based on post-exercise heart rate recovery. Of the 135 study subjects, 27 (20%) had cardiac autonomic neuropathy, the criteria for which included > 2 of 7 autonomic function markers (4 cardiac reflex tests and 3 indices of short-term heart rate variability). The optimal cut-offs for post-exercise heart rate recovery at 1-, 2-, and 3-minutes were < 28, < 50, and < 52 beats per minute, respectively.
Read the article summary1 Effect of Metoprolol Versus Carvedilol on Outcomes in MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy) JACC - Journal of the American College of Cardiology, April 3, 2013
2 Rate versus rhythm control for management of atrial fibrillation in clinical practice: Results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry American Heart Journal, April 1, 2013
3 The long QT syndrome: a transatlantic clinical approach to diagnosis and therapy European Heart Journal, April 9, 2013 Review Article
4 Effect of coenzyme q10 supplementation on statin-induced myalgias The American Journal of Cardiology, July 30, 2012
5 Chlorthalidone Versus Hydrochlorothiazide for the Treatment of Hypertension in Older Adults A Population-Based Cohort Study Annals of Internal Medicine, March 19, 2013
6 Statins and autoimmunity Immunologic Research, April 17, 2013 Review Article
7 Meta-Analysis of Carvedilol Versus Beta 1 Selective Beta-Blockers (Atenolol, Bisoprolol, Metoprolol, and Nebivolol) The American Journal of Cardiology, February 26, 2013 Evidence Based Medicine Review Article
8 Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial The Lancet, April 18, 2013
9 Clinical Update on the Management of Atrial Fibrillation Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, April 10, 2013
10 Treatment of Hypertension Among African Americans: The Jackson Heart Study The Journal of Clinical Hypertension, April 5, 2013
11 Outcomes of apixaban vs. warfarin by type and duration of atrial fibrillation: results from the ARISTOTLE trial European Heart Journal, April 22, 2013
12 Pulmonary hypertension: diagnosis and management British Medical Journal, April 23, 2013 Review Article
13 Effect of longer term modest salt reduction on blood pressure: Cochrane systematic review and meta-analysis of randomised trials British Medical Journal, April 25, 2013 Evidence Based Medicine Review Article
14 Infective Endocarditis New England Journal of Medicine, April 24, 2013 Review Article
15 Novel oral anticoagulants for stroke prevention in atrial fibrillation: a focus on the older patient International Journal of General Medicine, April 2, 2013 Free full text
16 Comparison of Prasugrel and Ticagrelor Loading Doses in ST-Segment Elevation Myocardial Infarction Patients RAPID (Rapid Activity of Platelet Inhibitor Drugs) Primary PCI Study JACC - Journal of the American College of Cardiology, April 12, 2013
17 Combination therapy in the management of pulmonary arterial hypertension International Journal of Clinical Practice, April 15, 2013 Review Article
18 A double-blind, double-dummy, randomized, placebo-controlled trial to evaluate the effect of statin therapy on triglyceride levels in Mexican hypertriglyceridemic patients Current Medical Research and Opinion, April 16, 2013
19 Long-term clinical follow-up of the multicenter, randomized study to test immunosuppressive therapy with oral prednisone for the prevention of restenosis after percutaneous coronary interventions: Cortisone plus BMS or DES veRsus BMS alone to EliminAte Restenosis (CEREA-DES) European Heart Journal, April 11, 2013
20 Can Vitamin D Supplementation Improve the Severity of Congestive Heart Failure? Congestive Heart Failure, April 2, 2013 Free full text
Indexed Journals in Cardiology: American Heart Journal, American Journal of Cardiology, Circulationn, Heart more
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