Statin use associated with decreased mortality in HFPEF
Based on a meta-analysis reported in the American Journal of Cardiology, statin use by patients (n=17985) with heart failure with preserved ejection fraction (HFPEF) is associated with a 40% reduction in mortality.
Vitamin D supplementation improves ejection fraction
As reported in Nutrition, Metabolism, and Cardiovascular Diseases, vitamin D supplementation (4000 IU/d of cholecalciferol x 6 months) of vitamin D-deficient heart failure patients (n=23) resulted in an increase in the ejection fraction compared to placebo (6.7 vs. -4.3%).
Rho-associated kinase activity is a biomarker for cardiovascular events
As reported in Hypertension, rho-associated kinase activity is an independent predictor of cardiovascular events. The study involved 633 patients undergoing routine health screening examinations with a median follow-up of 42 months. There were 29 cardiovascular-related deaths, 2 myocardial infarctions, 20 revascularizations, 15 strokes, and 17 hospitalizations for heart failure. The HRs for first cardiovascular event, death, stroke, and revascularization were 2.19, 2.57, 2.14, and 2.68, respectively.