The Latest Clinical Articles in Cardiology & Cardiovascular

1Novel oral anticoagulants (NOAC) and reversal agents: considerations for clinical developmentAmerican Heart Journal, March 27, 2015  Clinical Article
2Supervised versus unsupervised exercise for intermittent claudication: a systematic review and meta-analysisAmerican Heart Journal, March 27, 2015  Clinical Article
3Clinical evidence for oral antiplatelet therapy in acute coronary syndromesThe Lancet, March 27, 2015  Clinical Article  Evidence Based Medicine
4Genetic and immunologic susceptibility to statin-related myopathyAtherosclerosis, March 27, 2015  Review Article
5A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): A randomised controlled trialThe Lancet, March 27, 2015  Clinical Article  Evidence Based Medicine
6The effect of tree nut, peanut, and soy nut consumption on blood pressure: A systematic review and meta-analysis of randomized controlled clinical trialsAmerican Journal of Clinical Nutrition, March 27, 2015  Clinical Article  Evidence Based Medicine  Review Article
7Effects of the oriental herbal medicine Bofu-tsusho-san in obesity hypertension: A multicenter, randomized, parallel-group controlled trial (ATH-D-14-01021.R2)Atherosclerosis, March 27, 2015  Clinical Article
8Vitamin D status, hypertension and ischemic stroke: A clinical perspectiveJournal of Human Hypertension, March 27, 2015  Clinical Article
9The effect of everolimus initiation and calcineurin inhibitor elimination on cardiac allograft vasculopathy in de novo recipients: One-year results of a Scandinavian Randomized TrialAmerican Journal of Transplantation, March 27, 2015  Clinical Article
10The effects of aldosterone antagonists in patients with resistant hypertension: a meta-analysis of randomized and nonrandomized studiesAmerican Journal of Hypertension, March 27, 2015  Evidence Based Medicine  Review Article
1Merck announces collaboration with the American Diabetes Association to educate adults with diabetes about increased risk for serious diseases like pneumococcal pneumonia Merck, March 27, 2015
2FDA Drug Safety Communication: FDA warns of serious slowing of the heart rate when antiarrhythmic drug amiodarone is used with hepatitis C treatments containing sofosbuvir (Harvoni or Sovaldi) in combination with another direct acting antiviral drugFDA What's New: Drugs, March 26, 2015
3Risk factors associated with overweight cluster already in children University of Eastern Finland News, March 26, 2015
4American College of Physicians joins HHS in accelerating alternative payment methods through ‘Health Care Payment Learning and Action Network’ American College of Physicians News, March 26, 2015
5Nearly a decade apart, husband and wife get lifesaving heart implant to prevent strokesCedars-Sinai, March 24, 2015
6Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart diseaseNature, March 24, 2015
7ACC 2015: Newer heart risk calculator may better accounts for racial differencesEmory's Woodruff Health Sciences Center News, March 19, 2015
8Protein that helps cells stick together may explain heart disease developmentNorthwestern Medicine News, March 19, 2015
9Decline in heart health can start in childhoodAmerican Heart Association News, March 19, 2015
10New treatments for blood clots on horizonMonash University News, March 19, 2015

Show Me:

Statin use associated with decreased mortality in HFPEF

Based on a meta-analysis reported in the American Journal of Cardiology, statin use by patients (n=17985) with heart failure with preserved ejection fraction (HFPEF) is associated with a 40% reduction in mortality.

Vitamin D supplementation improves ejection fraction

As reported in Nutrition, Metabolism, and Cardiovascular Diseases, vitamin D supplementation (4000 IU/d of cholecalciferol x 6 months) of vitamin D-deficient heart failure patients (n=23) resulted in an increase in the ejection fraction compared to placebo (6.7 vs. -4.3%).

Rho-associated kinase activity is a biomarker for cardiovascular events

As reported in Hypertension, rho-associated kinase activity is an independent predictor of cardiovascular events. The study involved 633 patients undergoing routine health screening examinations with a median follow-up of 42 months. There were 29 cardiovascular-related deaths, 2 myocardial infarctions, 20 revascularizations, 15 strokes, and 17 hospitalizations for heart failure. The HRs for first cardiovascular event, death, stroke, and revascularization were 2.19, 2.57, 2.14, and 2.68, respectively.

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Clinical Pearls

Clinical Pearl from Smartest DocSevere TR should be fixed surgically in patients undergoing mitral valve surgery.

Clinical Pearl from Smartest DocAlterations in cardiac function and morphology observed in obesity start early in life.

Clinical Pearl from Smartest DocRadionuclide imaging is recommended as appropriate after PCI in the absence of symptoms.

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