1Effects of a High-Protein/Low-Carbohydrate versus a Standard Hypocaloric Diet on Weight and Cardiovascular Risk Factors during 9 Months: Role of a Genetic Variation in the Cannabinoid Receptor Gene (CNR1) (G1359A Polymorphism)Annals of Nutrition and Metabolism  Clinical Article
2Effects of rivaroxaban versus warfarin on hospitalization days and other health care resource utilization in patients with nonvalvular atrial fibrillation: an observational study from a cohort of matched usersClinical Therapeutics  Clinical Article
3Nicotinamide adenine dinucleotide phosphate oxidase-4–dependent upregulation of nuclear factor erythroid–derived 2-like 2 protects the heart during chronic pressure overloadHypertension  Clinical Article
4Early results of first versus second generation Amplatzer occluders for left atrial appendage closure in patients with atrial fibrillationClinical Research in Cardiology  Clinical Article
5Single- versus multi-phase acquisition protocol for prospective-triggered sequential dual-source CT coronary angiography: comparison of image quality and radiation doseClinical Imaging  Clinical Article
6Intravenous morphine administration and reperfusion success in ST-elevation myocardial infarction: Insights from cardiac magnetic resonance imagingClinical Research in Cardiology  Clinical Article
7Mediterranean diet and non-fatal acute myocardial infarction: A case-control study from ItalyPublic Health Nutrition  Clinical Article
8Safety and efficacy of LCZ696, a first-in-class angiotensin receptor neprilysin inhibitor, in Japanese patients with hypertension and renal dysfunctionHypertension Research  Clinical Article
9Angiotensin II receptor blockers decrease serum concentration of fatty acid-binding protein 4 in patients with hypertensionHypertension Research  Clinical Article
10Cardioverter defibrillator implantation without induction of ventricular fibrillation: a single-blind, non-inferiority, randomised controlled trial (SIMPLE)The Lancet  Clinical Article  Evidence Based Medicine
1New program extends health education, support for heart failure patients after hospital dischargeAmerican Heart Association News
2FDA drug safety communication: FDA cautions about using testosterone products for low testosterone due to aging; requires labeling change to inform of possible increased risk of heart attack and stroke with useFDA What's New: Drugs
3Study shows who benefits most from statinsWashington University School of Medicine in St. Louis News
4Tuesday news tips - American Heart Association EPI/Lifestyle 2015 meetingAmerican Heart Association News
5Endocrine Society publishes comprehensive report on hormone health statistics: Introductory chapter of Endocrine Facts and Figures report spotlights obesityEndocrine Society News
6NIH grant to support study of heart's inner mechanismsWashington University School of Medicine in St. Louis News
7Friends may make the difference in keeping children activeAmerican Heart Association News
8Published outcomes announced from study on adolescent bariatric surgery safetyNationwide Children's Hospital
9A new model shows that the filaments in heart muscle cells don't automatically keep the beatWeizmann Institute of Science News
10New views of enzyme structures offer insights into metabolism of cholesterol, other lipidsUniversity of Michigan Health System

Show Me:

Statin use associated with decreased mortality in HFPEF

Based on a meta-analysis reported in the American Journal of Cardiology, statin use by patients (n=17985) with heart failure with preserved ejection fraction (HFPEF) is associated with a 40% reduction in mortality.

Vitamin D supplementation improves ejection fraction

As reported in Nutrition, Metabolism, and Cardiovascular Diseases, vitamin D supplementation (4000 IU/d of cholecalciferol x 6 months) of vitamin D-deficient heart failure patients (n=23) resulted in an increase in the ejection fraction compared to placebo (6.7 vs. -4.3%).

Muscle strength in adolescence decreases CVD risk

As reported in BMC Medicine, adolescents (n=38588) with the highest tertile of muscle strength had a decreased risk of CVD (HR=0.88) compared to adolescents with the lowest tertile of muscle strength after 42 y of follow-up. Of note, low muscle strength in adolescence by itself had no effect on CVD risk in middle age (HR=0.99). In contrast, high muscle strength in adolescence significantly decreased the risk of CVD in middle age (HR=1.31).

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Clinical Pearls

Clinical Pearl from Smartest DocInvasive methods provide better quality of life than fibrinolysis and non-invasive treatment in patients with ACS.

Clinical Pearl from Smartest DocCRT does not reduce HF or death in patients with RBBB.

Clinical Pearl from Smartest DocHydration index assessment is useful for diagnosis and prognosis among patients with suspected acute heart failure.

The Top Read Articles of 2014 are Now Available

Scouring thousands of peer-reviewed journals and popular press, Our Editors just released the Top Read Articles of the Year. See the Top Read List