Acute responses to inhalation of Iloprost in patients with pulmonary hypertension Full Text
Chinese Medical Journal, 08/21/2012
Clinical Article
Hong–liang Z et al. – Inhalation of 20 μg Iloprost showed potent and selective pulmonary hemodynamic effects and was well tolerated in the Chinese pulmonary hypertension patients. Patients with idiopathic pulmonary arterial hypertension (PAH) and less severe pulmonary hypertension responded more favorably to inhalation of Iloprost.
Methods- Between March 2005 and May 2010, 212 pulmonary hypertension patients inhaled a single dose of 20 μg Iloprost over 10–15 minutes for vasoreactivity testing.
- The acute hemodynamic and oxygenation responses and adverse events were recorded.
- Iloprost decreased total pulmonary resistance ((1747±918) dyn×s×cm–5 vs. (1581±937) dyn×s×cm–5, P <0.001), increased stroke volume ((45.0±22.1) ml vs. (47.0±24.2) ml, P=0.002), and cardiac output ((3.7±1.7) L/ml vs. (3.9±1.9) L/min, P=0.009).
- Heart rate and systemic vascular resistance remained stable during inhalation.
- However, systemic arterial blood oxygen saturation fell slightly ((91.0±6.8)% vs. (90.3±6.7)%, P=0.002).
- Pulmonary and systemic arterial blood pressures declined within 1–3 minutes after inhalation initiation and reached their lowest levels within 10–15 minutes.
- Idiopathic PAH responded more favorably than pulmonary hypertension due to other causes (P £0.001) and patients with less severe pulmonary hypertension have better responses to Iloprost.
- No adverse events requiring medical care or leading to termination of inhalation occurred.
