Statin intake is associated with decreased insulin sensitivity during cardiac surgery
Diabetes Care, 07/27/2012
Sato H et al. – Preoperative use of lipophilic statins is associated with increased insulin resistance during cardiac surgery in nondiabetic, dyslipidemic patients.Methods
- In this prospective, nonrandomized trial, patients taking lipophilic statins were assigned to the statin group and hypercholesterolemic patients not receiving any statins were allocated to the control group.
- Insulin sensitivity was assessed by the hyperinsulinemic–normoglycemic clamp technique during surgery.
- The mean, SD of blood glucose, and the coefficient of variation (CV) after surgery were calculated for each patient.
- The association between statin use and intraoperative insulin sensitivity was tested by multiple regression analysis.
- Authors studied 120 patients.
- In both groups, insulin sensitivity gradually decreased during surgery with values being on average 20% lower in the statin than in the control group.
- In the statin group, the mean blood glucose in the intensive care unit was higher than in the control group (153 ± 20 vs. 140 ± 20 mg/dL; P < 0.001).
- The oscillation of blood glucose was larger in the statin group (SD, P < 0.001; CV, P = 0.001).
- Multiple regression analysis showed that statin use was independently associated with intraoperative insulin sensitivity (β = –0.16; P = 0.03).