Constitutive phosphorylation of inhibitor-1 at Ser67 and Thr75 depresses calcium cycling in cardiomyocytes and leads to remodeling upon aging
Basic Research in Cardiology , 08/01/2012
Florea S et al. – The results indicate that phosphorylation of I–1 at Ser67 and Thr75 is associated with increased PP1 activity and depressed cardiomyocyte Ca2+–cycling, which manifests in geometrical alterations over the long term. Thus, hyperphosphorylation of these sites in failing hearts may contribute to deteriorative remodeling.