Pkcα activation of p120-catenin serine 879 phospho-switch disassembles ve-cadherin junctions and disrupts vascular integrity
Circulation Research, 07/13/2012
St Amant EV et al. – PKCα phosphorylation of p120 at S879 is a critical phospho–switch mediating disassociation of p120 from VE–cadherin that results in AJ disassembly. Therefore, blocking PKCα–mediated p120 phosphorylation represents a novel targeted anti–inflammatory strategy to prevent disruption of vascular endothelial barrier function.