The effect of ondansetron and meperedin on preventing shivering after off-pump coronary artery bypass graft Full Text
Acta Medica Iranica, 07/11/2012
Abdollahi MH et al. – According to the findings, it was demonstrated that ondansetron is more effective in preventing shivering after Off–pump Coronary Artery Bypass Graft than meperedine.Methods
- In this double–blind randomized clinical trial, the sample consisted of 90 patients, who were candidates of CABG under general anesthesia.
- These patients were assigned to three groups, each containing 30 subjects: meperedine group (A), ondansetron group (B) and control group (C).
- Group (A) received 0.4 mg/Kg/IV of meperedine, group (B) received 8mg/IV of ondansetron and group (C) received Normal Saline.
- All these drugs were injected 15 minutes before the end of surgery.
- After the end of surgery, the intubated patients were transferred to the ICU and their body temperature was assessed through eardrum by a specialist who was blind to the research.
- The incidence of shivering in groups A, B, and C was 46.48%, 31.18%, and 60.83%, respectively (P=<0.01).
- The incidence of shivering was 64.4% in males and 35.6% in females (P=0.222).
- Also, the amount of incidence of shivering up to 3 hours after surgery was 75.87 % (P=0.064).
- Bradycardia was 3.3% in group (A) and 0.0 % in group (B).
- Other variables (myoclonus, seizure and rash) showed no statistically significant difference (P=0.353).