Effect of high-dose rosuvastatin loading before percutaneous coronary intervention in female patients with non-ST-segment elevation acute coronary syndrome Full Text
Chinese Medical Journal, 07/13/2012
Yuan G et al. – High–dose rosuvastatin loading before percutaneous coronary intervention (PCI) significantly reduced periprocedural myocardial injury and periprocedural inflammation cytokines release and improved 3–month and 6–month clinical outcomes in female patients with non–ST–segment elevation acute coronary syndrome (NSTEACS) who underwent PCI.Methods
- Consecutive 117 female patients with NSTEACS were randomly assigned to either the group of rosuvastatin loading before PCI (20 mg 12 hours before angioplasty procedure, with a further 10 mg dose 2 hours before procedure, the loading dose group, n=59) or the no rosuvastatin treatment group before PCI (control group, n=58).
- Periprocedural myocardial injury, periprocedural changes of high sensitivity C–reactive protein (hs–CRP), interleukin (IL)–1, IL–6, and tumor necrosis factor (TNF)–a in serum and the incidence of major adverse cardiac events (MACE) 3 months and 6 months later were assessed.
- The incidence of periprocedural myocardial injury was higher in control group than loading dose group (CKMB: 10.17% vs. 25.86% , P=0.027; Troponin I: 11.86% vs. 29.31%, P=0.019).
- MACE occurred in 1.69% of patients in loading dose group and 12.07% of those in control group 3 months after procedure (P=0.026), 3.39% vs. 17.24% at 6 months (P=0.014).
- The levels of hs–CRP, IL–1, IL–6, and TNF–a in serum were not significantly different between the two groups before PCI, but after PCI they were significantly higher in control group.