Beta-blockers use and risk of hyperglycemia in acute stroke patients
Dziedzic T et al. – Beta–blockage before stroke onset may result in lower plasma glucose on admission and prevent early hyperglycemia in patients without pre–stroke diagnosis of diabetes mellitus.Methods
- Authors analyzed the data of 603 consecutive patients with acute ischemic stroke and without pre–stroke diagnosis of diabetes mellitus admitted to stroke unit within 24 h after symptoms onset.
- Plasma glucose level on admission (6.0 ± 1.4 vs 6.6 ± 1.9 mmol/L, P = 0.01) and fasting glucose on day 1 (5.2 ± 1.1 vs 5.7 ± 1.1 mmol/L, P = 0.02) were significantly lower in patients treated with beta–blockers before stroke than in those who did not receive such a treatment.
- On multivariate logistic analysis beta–blockers use before stroke was associated with reduced risk of glucose level on admission ≥7.8 mmol/L (OR: 0.22, 95%CI: 0.07–0.74) and fasting glucose on day 1 ≥ 7.0 mmol/L (OR: 0.21, 95%CI: 0.05–0.91).
- The risk of fasting hyperglycemia defined as glucose ≥6.1 mmol/L did not differ between groups.