Shear stress modulates the expression of the atheroprotective protein Cx37 in endothelial cells
Journal of Molecular and Cellular Cardiology, 07/18/2012
Pfenniger A et al. – GJIC dye transfer was highly reduced after KLF2 silencing and was increased after exposure to simvastatin. HLSS upregulates the expression of Cx37 in ECs by inducing its transcription factor KLF2, which increases intercellular communication. Therefore, this effect of shear stress on Cx37 expression may contribute to the synchronization of ECs and participate in the protective effect of HLSS.